The possible modulatory effects of kolaviron on arsenite-induced hepato-toxicity in experimental rats
1 Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
* Corresponding author: hannafiazeezat@yahoo.com
* Corresponding author: hannafiazeezat@yahoo.com
Abstract
The effects of kolaviron , an active component of Garcinia kola seeds were investigated on sodium arsenite-induced hepatotoxicity in rats. Administration of a single dose of sodium arsenite (10mg/kg body weight) orally, increased the activities of serum marker enzymes-Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT). This also led to increase in lipid peroxidation and reduction in the activities of antioxidant enzymes such as superoxide dismutase(SOD) and catalase(CAT). Treatment with 100mg/kg body weight of kolaviron for thirteen days before and after induction of arsenite toxicity reduced the serum activities of ALT and AST significantly (p
Keywords
Kolaviron
Sodium Arsenite
Lipid peroxidation
Antioxidants
Hepatotoxicity.
How to Cite
O, O. H., & AKUNNA, T. (2015). The possible modulatory effects of kolaviron on arsenite-induced hepato-toxicity in experimental rats. Nigerian Journal of Material Science and Engineering, 6(1), 124-129.
O. H. O, and T. AKUNNA, "The possible modulatory effects of kolaviron on arsenite-induced hepato-toxicity in experimental rats," Nigerian Journal of Material Science and Engineering, vol. 6, no. 1, pp. 124-129, June 2015.
