Research Article

The possible modulatory effects of kolaviron on arsenite-induced hepato-toxicity in experimental rats

OLUFUNMILAYO HANNAFI O1*, THEODORE AKUNNA1
1 Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
* Corresponding author: hannafiazeezat@yahoo.com
Published: Jun, 2015
DOI: 10.67656/njmse.2015.c1diln1q
Pages: 124-129
Views: 117
Downloads: 98

Abstract

The effects of kolaviron , an active component of Garcinia kola seeds were investigated on sodium arsenite-induced hepatotoxicity in rats. Administration of a single dose of sodium arsenite (10mg/kg body weight) orally, increased the activities of serum marker enzymes-Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT). This also led to increase in lipid peroxidation and reduction in the activities of antioxidant enzymes such as superoxide dismutase(SOD) and catalase(CAT). Treatment with 100mg/kg body weight of kolaviron for thirteen days before and after induction of arsenite toxicity reduced the serum activities of ALT and AST significantly (p

Keywords

Kolaviron Sodium Arsenite Lipid peroxidation Antioxidants Hepatotoxicity.

References

  1. Akintonwa A., Essien A.R., 1990: Protective effects of Garcinia kola seed extract against paracetamol induced hepatotoxicity in rats. Journal of ethnopharmacology 29: 207-217
  2. Benramdane L., Accomintti M., Fanton L., Malicier D., Vatton J.J 1999: Arsenic Speciationin human organs following fatal arsente trioxide poisoning- a case report. Clinicalchemistry. 45(2): 301-306
  3. Bishayi B. 2000: Sodium arsenite-induced alteration in functional activity of murine _ peritoneal Macrophages. Indian Journal of pharmacology. 32:192-197
  4. Cotterhill P.I., Scheinmarin F., Stenhouse T.A. 1978: Extractives from Guttiferae: kolaflavonone, a new biflavonone from the nuts of Garcinia kola heckel Journal of Chemical Society. perkin Trans 1:246
  5. Di Carlo G., Mascolo N.,Izzo A.A., Capasso F. 1999: Flavonoids: old and new aspect of a class of natural therapeutic drugs. Life Sciences. 65(4): 337-353.
  6. Farombi E.O., Moller P., Dragsted L.o. 2004: ex-vivo and in-vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rats liver cells. Cell Biology and Toxicology 20:71-82
  7. Farombi E.O., Tahnteng J.G., Agboola O., Nwakwo J.O., Emerole G.O. 2000a: Chemoprevention 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation In rats by kolaviron- a Garcinia kola seed extract. Food and Chemical Toxicology 38(6):535-541
  8. Farombi E.O. 20002 Mechanism for the hepatoprotective action of kolaviron: studies on Hepaticenzymes and microsomal lipids and lipid peroxidation in carbon tetrachloride- treated rats. Pharmacology Research 42:75-80
  9. Habig W.H., Pabst M.J., Jacoby W.B., 1974: Glutathione-s-transferase. The first step in mercapturic acid formation. Journal of Biochemistry 249:7130-7139.
  10. IPCS 1996: Guide lines for drinking water quality. Health criteria. and other supporting information. 2(2). Geneva . WHO.
  11. Iwu MM., Igboko O.A., Okunji C.O., and Tempesta M.S. 1990: Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. Journal of Pharmacy Pharmacology42(4):290-292.
  12. Iwu MM., Igboko O.A., Onwuchekwa U.A., Okunji C.O. 1987: Evaluation of the anti-hepatotoxicactivities of biflavonoid of Garcinia _kola seed. Journal of Ethnopharmacology 21 (2): 127-138.
  13. Jollow D.J., Michelle J.R., Zampaglionic and Gillete J.R.,1974: Bromobenzene-induced liver necrosis:protective role of glutathione and evidence for 3,4-bromobenzene oxide as hepatotoxic metabolite. Pharmacology. 11:151-169.
  14. Lee T.C., Ho LC. 1994: Differential cytotoxic effects of arsenic on human and animal cells. Environ. Health, Perspect. 102:101-105
  15. Leolavinothan Pari and D. Rosalin Amali. 2004: Protective role of tetra hydrocurcumin (THC)- an active principle of turmeric on chloroquine induced hepatotoxicity in rats. Journal of pharmacy and pharmaceutical science.8:115-123
  16. Masuda T., Maekawa T., Hidaka K., Bando H., Takeda Y., Yamaguchi H., 2001: Chemical studies on antioxidant mechanism of curcumin: analysis of oxidative coupling —_Productsfrom curcuminand linoleate. Journal of Agricultural and food chemistry. 49(5):2539-2547
  17. Misra H.P. and Fridovish I., 1972: The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. The journal of biological chemistry. 247:3170-3175
  18. Pompella A.,Visvikis A., Paolicchi A., Tata V., Casini AF. 2003: The changing faces of glutathione- a Protagonist. Biochemical Pharmacology 66(8):1499-1503
  19. Ramos O., Carrizales L., Yanez L.,Barriga F., 1995: Arsenic increased lipid peroxidation in rats by a mechanism independent of glutathione levels. Environmental Health Perspective. 103(1): 85- 88.
  20. Reiter R.J., 1995: Oxidative processes and antioxidative mechanism in the aging brain. Federation of American Society for Experimental biology 9:526-53:526-53
  21. Sallie R., Tredger J.M., William R. 1991: Drugs and the liver part testing liver functions. Biopharmaceutics Drug Disposition 12: 251-259
  22. Santra A., Maiti A., Das S., Lahiri $.,Charkaboty S.K., Guha Mazunder D.N. 2000: Hepatic damage caused by chronic arsenic toxicity in experimental animals. Clinical Toxicology38: 395-405
  23. Scott M.D.,Lubin B.H., Zuo L., Kuypers F.A. 1991: Erythrocyte defence against Hydrogenperoxide pre eminent importance of catalase. Journal of laboratory and clinical medicine] 18:7-16
  24. Shen J., Wanibuchi H., Salim E.1, Wei M., Kinoshita A., Yoshida K., Endo G., FukushimaS. 2003: Liver tumorigenicity of trimethylarsineoxide in male fischer 344 rats. Association with oxidative DNA damage and enhanced cell proliferation. Carcinogenesis. 24:1827-1835
  25. Sinha K.A., 1971: Colometric assay of catalase. Analytical Biochemistry journal. 47:389- 94
  26. Sqibb K.S., Fowler B.A. 1983: The toxicity of arsenic and its compounds. In: Fowler B.A, biologicalenvironmental effects of arsenic. Amsterdam: Elsevier science publishers, 233-269.
  27. Sreejayan N., Rao M.N. 1994: Curcuminoids as potent inhibitors of lipid peroxidation. Journal of Pharmacy and pharmacology 46:1013-1016
  28. Terashima K., Aqil M., Niwa M. 1995: A novel biflavanones from the roots of Garcinia kola. Heterocycles 41:2245-2250
  29. Tseng J.H., Kao E.S., Chu C.Y.,Chiou F.P., Linwu H.W., Wang W.C.. 1991: Protective effects of dried Flower extract of Hibiscus sabdariffa. L. against oxidative stress in rats primary hepatocyte Food and Chemical Toxicology. 35:1159-1164
  30. Varshney R. and Kale R.K. 1990: Effects of calmodulin antagonist on radiation induced lipid peroxidation in microsome. International Journal of Radiation Biology. 58(5):733- 743
  31. Waldron H.A., Scott A. 1994: Metals-Arsenic, In: Raffle PAB. Adams P.H., Baxter P,j., Lee W.R. eds. Hunter's disease of occupation. 8th edition. London: Edwin Amold. 109-112.
How to Cite

O, O. H., & AKUNNA, T. (2015). The possible modulatory effects of kolaviron on arsenite-induced hepato-toxicity in experimental rats. Nigerian Journal of Materials Science and Engineering, 6(1), 124-129. https://doi.org/10.67656/njmse.2015.c1diln1q

O. H. O, and T. AKUNNA, "The possible modulatory effects of kolaviron on arsenite-induced hepato-toxicity in experimental rats," Nigerian Journal of Materials Science and Engineering, vol. 6, no. 1, pp. 124-129, June 2015. doi: 10.67656/njmse.2015.c1diln1q

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